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Immediate ART Initiation Reduces Risk of
Infection-Related Cancer in HIV Infection/START Study
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'significant reduction in cancer risk by 64%....benefits of ART become evident after 12 months and continue through the entire followup....results were surprising & unexpected because START recruited young patients with average age of 36 with higher CD4s, over 500, and early HIV....cancer rates remain stable in immediate ART group through the entire followup while in the deferred ART group cancer event rates increased after 12 months & continued increasing through the entire followup, and this was a significant increase.....infection related cancers were significantly reduced by 74% with immediate ART...for infection-unrelated cancers the risk reduction with immediate ART was 51% but it was not significant but data suggests with longer followup & more cancer events the risk reduction might have proven to be significant.....baseline HIV-RNA (viral load) was associated with higher risk for infection-related cancers'
Reported by Jules Levin
CROI 2016 Feb 22-24 Boston
WEBCAST link to oral presentation by Dr Borges:
http://www.croiwebcasts.org/console/player/29714?mediaType=audio&
Alvaro H. Borges1; Jacqueline Neuhaus2; Abdel Babiker3; Timothy J. Wilkin4; Christian Hoffmann5; Keith Henry6; Adrian Palfreeman7; Mamta K. Jain8; Sanjay Pujari9; Ronald T. Mitsuyasu10; for the for the INSIGHT START study group
1Rigshospitalet, Univ of Copenhagen, Copenhagen, Denmark;2Univ of Minnesota, Minneapolis, MN, USA;3Univ Coll London, London, UK;4Weill Cornell Med Coll, New York, NY, USA;5IPM StudyCntr, Hamburg and Univ of SchleswigHolstein, Campus Kiel, Hamburg, Germany;6Hennepin County Med Cntr, Univ of Minnesota, Minneapolis, MN, USA;7Med Rsr Council Clinical Trials Unit, London, UK;8Univ of Texas Southwestern Med Cntr, Dallas, TX, USA;9Inst of Infectious Diseases, Pune, India;10Univ of California Los Angeles, Los Angeles, CA, USA
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