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Adipose Tissue [belly, subcutaneous] and HIV infection
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"Adipose tissue CD4 T cells and macrophages are infected with SIV....HIV-infected cells are present in adipose tissue samples from ART-treated, a viremic patients.....HIV virus within adipose tissue CD4 T lymphocytes is competent for replication.....SIV infection induces alterations in both adipocytes and adipose immune cells.....Chronic SIV infection induces an accumulation of CD8 T cells and a preservation of CD4 T cells number [in adipose].....Adipose CD4 T cells are localized within adipose tissue whereas adipose CD8 T cells are in the perivascular area."
Reported by Jules Levin
CROI 2016 Feb 22-24 Boston
A Damouche, T Lazure, V Avettand-Fenoel, N Huot, N Dejucq-Rainsford, C Rouzioux, J Capeau, M Muller-Trutwin, N Dereuddre-Bosquet, R Le Grand, O Lambotte et C Bourgeois.
INSERM U1184, Faculte de Medecine Paris SUD, Le Kremlin-Bicetre / CEA, Division of Immuno-virology, iMETI, Fontenay-aux-Roses, France
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