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More Coffee Tied to Lower Mortality in French HIV/HCV Group
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Conference on Retroviruses and Opportunistic Infections (CROI), February 22-25, 2016, Boston
Mark Mascolini
Drinking more than 3 cups of coffee daily halved the risk of death--independently of CD4 count and HCV clearance--in a study of more than 1000 HIV/HCV-coinfected people in the French ANRS HEPAVIH cohort [1]. The researchers surmise that antiinflammatory and antifibrotic properties of coffee may explain a finding sure to please java fanciers.
The ANRS team who conducted this study noted that previous research linked more than 3 cups of coffee daily to reduced risk of insulin resistance and lower liver enzyme levels. They conducted this study to assess the impact of coffee drinking and other behaviors on mortality in HIV/HCV-coinfected HEPAVIH cohort members.
HEPAVIH is an ongoing study that has enrolled 1246 coinfected people across France since 2006. Participants make once-a-year study visits. The 1035 people eligible for this analysis had a median follow-up of 5 years. During that time 77 people (7.4%) died of any cause. Mortality stood at 1.64 per 100 person-years (95% confidence interval [CI] 1.31 to 2.05). The largest numbers of deaths (33, or 42.8%) were attributed to HCV-related causes including hepatocellular carcinoma. Non-AIDS non-HCV cancers explained 9 deaths (11.7%), and AIDS accounted for 8 deaths (10.4%).
In multivariate analysis unstable housing almost quadrupled the risk of death (adjusted hazard ratio [aHR] 3.7, 95% CI 1.9 to 7.3), and having a CD4 count at or below 200 tripled the death risk (aHR 3.2, 95% CI 1.9 to 5.5). Three nonbehavioral factors lowered the risk of death: being treated for HCV infection and cured (aHR 0.2, 95% CI 0.1 to 0.6), having a steady partner (aHR 0.6, 95% CI 0.3 to 0.9), and being a woman (aHR 0.6, 95% CI 0.3 to 1.0).
Compared with drinking no alcohol, having 1 or fewer drinks daily halved the risk of death (aHR 0.5, 95% CI 0.3 to 0.9), but moderate drinking (1 to 4 drinks a day) had no impact on mortality. Compared with past or current smokers, people who never smoked had a 70% lower risk of death (aHR 0.3, 95% CI 0.1 to 0.9). And compared with drinking fewer than 3 cups of coffee daily, drinking 3 or more cups halved the risk of death (aHR 0.5, 95% CI 0.3 to 1.0, P = 0.045). The link between more coffee drinking and lower death risk was independent of CD4 count and HCV clearance.
The researchers believe their findings "underline the need [for] evaluating the benefits of coffee extracts and supplementary dietary intake of other antiinflammatory compounds in this population."
Reference
1. Carrieri P, Protopopescu C, Sogni P, et al. Protective effect of coffee intake on mortality of French HIV/HCV-infected patients. Conference on Retroviruses and Opportunistic Infections (CROI), February 22-25, 2016, Boston. Abstract 549.
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