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Is Intensive Cervical Cancer Screening
Justified in Immunosuppressed Women?
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Reported by Jules Levin
CROI 2016 Feb 22-24 Boston
Michael J. Silverberg1,2, Wendy A. Leyden1, Steven Gregorich3, Karen K. Smith-McCune4, Megan Huchko4, Miriam Kuppermann2,4, Shalini Kulasingam5, George F. Sawaya2,4
1 Division of Research, Kaiser Permanente, Oakland, CA
2 Department of Epidemiology and Biostatistics, UCSF
3 Department of Medicine, UCSF
4 Department of Obstetrics, Gynecology & Reproductive Sciences, UCSF
5 Division of Epidemiology and Community Health, School of Public Health, UMN
WEBCAST:http://www.croiwebcasts.org/console/player/29716?mediaType=audio&
CROI: Intensive Cervical Cancer Screening Needed Only at Lower CD4s in HIV+ Women - Mark Mascolini - (03/03/16).....
Women with HIV had twice higher odds of advanced cervical intraepithelial neoplasia (CIN) or cervical cancer than women without HIV......In adjusted analyses, compared with HIV-negative women, HIV-positive women had 2.0-fold higher odds of CIN2+ and 2.3-fold higher odds of CIN3+. HIV-positive women with a recent CD4 count under 200 CD4s had 5.7-fold higher odds of CIN2+ and women with 200 to 499 CD4s had 3.0-fold higher odds. But risk of CIN2+ was not greater in HIV-positive women with 500 or more CD4s compared with HIV-negative women. The same held true for the CIN3+ analysis: Odds were 5.4-fold higher with a recent CD4 count under 200 CD4s and 3.6-fold higher with 200 to 499 CD4s, but risk was no greater in women with 500 or more CD4s.
EACS: Long lasting viral suppression and immune reconstitution (CD4) of great magnitude reduce the risk of cervical dysplasia in HIV-positive women - (11/02/15)
Combination antiretroviral therapy reduces the detection risk of cervical human papilloma virus infection in women living with HIV.....http://www.natap.org/2014/HIV/120814_03.htm
CROI: Global Burden of Cervical Cancer in HIV-Positive Women on Antiretroviral Therapy - (03/10/16)
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