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Differences in Predictors for Ischaemic and Haemorrhagic Strokes in HIV+ Individuals
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"Of the HIV-related variables, only low CD4 count was associated with the risk of both stroke subtypes; previous AIDS and HIV acquisition via injection drug use (IDU) appeared to be more strongly associated with ischaemic strokes than were haemorrhagic strokes (Figure 2).....Age, elevated BP[blood pressure] and low CD4 count were the strongest predictors for both stroke subtypes....Our findings are similar to those reported in the general population and emphasize the importance of preventive measures and screening, using stratified predictors to provide more precise risk estimation for the different stroke subtypes in HIV+ individuals......Only male gender and IDU were found to have statistically significant predictive abilities for ischaemic and haemorrhagic strokes, respectively......In the general population, several shared risk factors for ischaemic and haemorrhagic strokes have been identified (hypertension, renal impairment, age, diabetes, prior stroke7), and hypertension and low estimated glomerular rate (eGFR-kidney function) may be more strongly linked to haemorrhagic strokes than ischaemic strokes8,9."
Reported by Jules Levin
CROI 2026 Feb 22-24 Boston
CI Hatleberg1, DA Kamara2, L Ryom1, S de Wit3, M Law4, P Reiss5, A D'Arminio Monforte6, C Pradier7, O Kirk1, H Kovari8, F Dabis9, JD Lundgren1, CA Sabin2
for the D:A:D Study group
1CHIP, Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; 2Research Department of Infection and Population Health, UCL, London, United Kingdom; 3Division of Infectious Diseases, Saint Pierre University Hospital, Universite Libre de Bruxelles, Brussels, Belgium; 4The Kirby Institute, UNSW Australia, Sydney, Australia; 5Academic Medical Center, Dept. of Global Health and Div. of Infectious Diseases, University of Amsterdam, and HIV Monitoring Foundation, Amsterdam, The Netherlands, 6Dipartimento di Scienze della Salute, Clinica di Malattie Infectitive e Tropicali, Azienda Ospedaliera-Polo Universitario San Paolo, Milan, Italy; 7Department of Public Health, Nice University Hospital, Nice, France; 8Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland; 9Universite de Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France
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