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Frailty is associated with NNRTI-based Initial ART and Modifiable Risks in ACTG 5322
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[from Jules Levin, NATAP - 60% frailty among 50-59 year old HIV+....39% pre-frail among 40-49 years old HIV+....NNRTI-based initial ART regimens were associated with frailty / Integrase inhibitors improve walking/gait....D4T/DDI use [any prior use] was associated with slower gait while INSTI use was protective.....Physical activity & some alcohol use were protective for both frailty & 4-m walk pace....Obesity & smoking were associated with greater frailty....Neurocognitive impairment & renal disease were associated with greater odds of frailty & slow 4-m walk pace.]
Reported by Jules Levin
CROI 2016 Feb 22-24 Boston
KM Erlandson1, K Wu2, SL Koletar3, R Kalayjian4, B Taiwo5, FJ Palella Jr5, K Tassiopoulos21University of Colorado, Aurora, CO, USA; 2Harvard T.H. Chan School of Public Health, Boston, MA, USA; , 3Ohio State University Medical Center, Columbus, OH, USA; MetroHealth, Cleveland, OH, USA; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
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