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Can we prevent HIV infection by focusing on the HIV target cell rather than the virus? Common Anti-inflammatory Medications Reduce HIV-Target Infection Cells Apparently Reducing Inflammation/Immune Activation & Creating "Immune Quiescence"
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from Jules: Common Anti-inflammatory Medications Low-Dose Aspirin & hydroxychloroquine Reduce Target Cells for HIV Infection / Apparently Reduces Inflammation Resulting in Reduced Immune Activation & Reduced HIV Target Cells, Creating "Immune Quiescence"
Reported by Jules Levin
HIV Research for Prevention (HIVR4P), October 17-19, 2016, Chicago
Keith R. Fowke1,2,4, Lucy Mwangi2,, Geneviève Boily-Larouche1, Maureen Akolo3, John Mungai3, Julianna Cheruiyot3,
Makubo Kimani3, Julius Oyugi1,2, Joshua Kimani1,2,3, Julie Lajoie1,2,
1Department of Medical Microbiology and Infectious Diseases, University of Manitoba, 2Department of Medical Microbiology, University of Nairobi,
3Kenyan AIDS Control Program, Nairobi; 4Department of Community Health Science, University of Manitoba
Hydroxychloroquine (HCQ),sold under the trade names Plaquenil among others, is an antimalarial medication. It is also used to reduce inflammation in the treatment of rheumatoid arthritis (see disease-modifying antirheumatic drugs) and lupus. Hydroxychloroquine differs from chloroquine by the presence of a hydroxyl group at the end of the side chain: the N-ethyl substituent is beta-hydroxylated. It is available for administration by mouth as hydroxychloroquine sulfate.....https://en.wikipedia.org/wiki/Hydroxychloroquine
https://en.wikipedia.org/wiki/Aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, and inflammation.[3] Specific inflammatory conditions in which it is used include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin given shortly after a heart attack decreases the risk of death. Aspirin is also used long-term to help prevent heart attacks, strokes, and blood clots in people at high risk.[3] Aspirin may also decrease the risk of certain types of cancer, particularly colorectal cancer.[4] For pain or fever, effects typically begin within 30 minutes.[3]
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