 |
|
|
| |
Phosphoramidate prodrugs of uridine analogs, including sofosbuvir, are metabolized to both uridine and cytidine triphosphates in Huh7 cells and primary human hepatocytes
|
| |
| |
Reported by Jules Levin
17th International Workshop on Clinical Pharmacology of HIV and Hepatitis Therapy, June 8-10, 2016, Washington DC
R. Bethell1, A. Lindqvist1, S. Juric1, C. Rydergard1, H. Westerlind1, A. Eneroth1, K. Wikstrom1, H. Kylefjord1, G. Kalayanov1, E. Lindström1, P. Targett-Adams1, P. Pinho1, A. Rosenquist1
1Medivir AB, R&D, Huddinge, Sweden
References:
1. MJ Sofia et al., J. Med. Chem. (2010), 53, 7202-7218;
2. 2. FDA review documentation (accessed May 29th 2016):
http://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/204671Orig1s000PharmR.pdf
|
| |
|
|
|
|
|
