icon-folder.gif   Conference Reports for NATAP  
  The Liver Meeting
Washington DC
October 2017
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Significant and Sustained Improvement of Health-Related
Quality of Life Scores in Patients with Hepatitis C
and Sustained Virologic Response

   from Jules: This study assessed long-term changes in HRQL in subjects with chronic HCV infection who have achieved SVR. It is 3 years followup from the Gilead registry: "The data came from the "Long Term Follow-up Registry for Subjects Who Achieve a Sustained Virologic Response to Treatment in Gilead-Sponsored Trials" ......Subjects with SVR by the original protocols' definitions were enrolled to participate in the registry for up to 3 years"......Patients completed forms at baseline and then every 24 weeks. the following were evaluated: Physical Functioning, Role Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role Emotional, Mental Health; and, Physical and Mental Summary scores and a preference-based utility SF-6D score. Improvements in all these areas of measure were seen after SVR and improvements persisted for 3 years after SVR...see ALL the specific results below, all the graphs of the results. Patients with depression, fatigue, insomnia and cirrhosis at baseline saw greater improvements.
Reported by Jules Levin
AASLD - American Association for The study of Liver Diseases (AASLD), October 20 - 24, 2017, Washington DC, USA
Zobair M. Younossi 1, Maria Stepanova 2, Edward J. Gane3, Ira M. Jacobson 4, David R. Nelson 5, Ashley S. Brown 6, Issah Younossi 2, Linda Henry 2
1. Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, United States
2. Center for Outcomes Research in Liver Disease, Washington DC, DC, United States 3. New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand 4. Mt. Sinai Beth Israel, New York, NY, United States
5. University of Florida, Gainesville, FL, United States
6. Liver & Antiviral Unit, Imperial College Healthcare NHS Trust, London, United Kingdom