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Long-Term Evaluation of Liver Stiffness and Blood
Markers in Hepatiti s C Virus Genotype 1-Infected Patients
Receiving Ombitasvir/Paritaprevir/Ritonavir + Dasabuvir ± Ribavirin: Interim Results from TOPAZ-I and TOPAZ-II - from Jules: TREAT EARLY
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Reported by Jules Levin
APASL 2017 Feb 15-19 Shanghai, China
from Jules: TREAT EARLY They checked Fibroscan 12, 24 & 52 weeks post SVR - take note the best chance of improving fibrosis is to treat at F1 where 99% remain stable at week 52 when checked by Firbroscan, IF you wait until F2 90% improve, if you wait until F3 81% improve, if you wait until F4 55% improve. BUT it may take years for fibrosis to realize its fullimprovement after SVR, take my personal case. I had cirrhosis when achieving SVR in 2001 withpeg interferon, but did not check Fibroscan until 3 years ago & then found it at F0. It may have taken many years to achieve this, longer than 52 weeks. Improvement may continue over many years.
Direct Acting Anti-Viral Therapy for Chronic Hepatitis C Virus Infection Is Associated with Regression of Liver Fibrosis, Assessed by Serial Transient Elastography (Fibroscan) - (11/11/16)
J George1, D Dieterich2, M Weltman3, R Skoien4, P Desmond5, J Sasadeusz6, KA Stuart7, P Dorr8, E Dumas8, M Charafeddine8, L Liu8, D Cohen8, P Marti n9, HS Te10, M Sulkowski 11, D Shaw12, F Poordad13
1Westmead Hospital, Westmead, New South Wales, Australia; 2Icahn School of Medicine at Mount Sinai, New York, New York, United States; 3Nepean Hospital, Kingswood, New South Wales, Australia; 4Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia; 5St. Vincents Hospital Melbourne, Fitzroy, Victoria, Australia; 6Royal Melbourne Hospital, Parkville, Victoria, Australia; 7Gallipoli Medical Research Foundati on, Greenslopes, Queensland, Australia; 8AbbVie Inc., North Chicago, Illinois, United States; 9University of Miami, Miami, Florida, United States; 10University of Chicago, Chicago, Illinois, United States; 11Johns Hopkins University, Lutheville, Maryland, United States; 12Royal Adelaide Hospital, Adelaide, South Australia, Australia; 13Texas Liver Insti tute, San Antonio, Texas, United States
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