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CHANGES IN THE ORAL MICROBIOME WITH ART INITIATION / Microbiome Affects of Low Baseline CD4/High Viral Load
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"Constrained correspondence analysis demonstrates that there are statistically significant differences in the microbiota of samples with low CD4 and high viral load.....participants with baseline CD4<200 and high viral load >100,000 exhibited differences in dominant taxa, demonstrating more Capnocytophaga ....Capnocytophagahas been associated with periodontal disease, which has been seen in HIV+ participants with advanced immune deficiency. These shifts are partly reversed by 24 wksof ART .....Conclusions: We demonstrated no overall significant shift in the salivary microbiome after 24 wks of ART. However, advanced HIV disease is associated with differences in the microbiome, which may be contributing to inflammation and periodontal disease in this population."
Reported by Jules Levin
CROI 2017 Feb 14-16 Seattle, WA
Rachel Presti1, Scott Handley2, Lindsay Droit2, Mahmoud Ghannoum3, Mark Jacobson4, Caroline H Shiboski4, Jennifer Webster-Cyriaque5, Todd Brown6, Michael T Yin7, Edgar T Overton8
1Washington University in St. Louis, St. Louis, MO, USA, 2Washington University School of Medicine, St. Louis, MO, USA, 3Case Western Reserve, Cleveland, OH, USA,4University of California, San Francisco, San Francisco, CA, USA, 5University of North Carolina, Chapel Hill, NC, USA, 6JHU, Baltimore , MD, USA, 7Columbia University Medical Center, New York, NY, USA, 8University of Alabama, Birmingham, AL, USA
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