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Older Age Associated with both Adherence and
Renal Decline in the PrEP Demo Project
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"Overall, eGFR (kidney function) declined by mean -3.2% (range -3.7 to +680 over 48 weeks (insistent with other studies....[older age is associated with better adherence & better adherence which is required to prevent HIV infection, can lead to greater decline in kidney function as measured by eGFR) Median age 34 (range 19-65) years; 99% MSM; 71% reported condomless receptive anal sex in past 3 months; 60% reported recreational drug use (13% amphetamine) in last 3 months (Table 1) - 82% (718) of person-visits demonstrated hair levels (≥0.023 ng/mg) consistent with "good adherence" (≥4 doses/wk14,15) "..... condomless sex & amphetamine use are associated with better adherence, see Table 2 below
Reported by Jules Levin
CROI 2017 Feb 14-16 Seattle, WA
Monica Gandhi1, Peter Bacchetti2, Catherine A. Koss1, Chengshi Jin2, Howard Horng3, Richard Elion4, Michael Kolber5, Stephanie Cohen6, Susan Buchbinder7, Albert Liu7 1Department of Medicine, Univ of California, San Francisco (UCSF), San Francisco, CA.; 2Department of Epidemiology and Biostatistics, UCSF; 5Department of Bioengineering and Therapeutic Sciences, UCSF;6 Whitman Walker Health Center Washington DC; 5University of Miami Miller School of Medicine, Miami, FL; 6San Francisco Department of Public Health, San Francisco, CA; 7Bridge HIV, SF Department of Public Health, San Francisco, CA
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