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Blood Brain Barrier function, ART neuroactivity and risk of CSF
HIV escape / BBB Permeability & Neurocognitive Performance in HIV+
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" Impaired BBB was defined by CSF/plasma albumin quotient x 103(Qalb), according to age-normalized reference ranges (Reiber,ClinChem,1995).......A positive correlation between Qalb and CSF/plasma ARV concentration ratio (R=0.686,p<0.001).....was found.....Conclusions. BBB dysfunction may influence neuropenetration (CSF/plasma drug concentration ratio) and efficacy (IQ95) of ARVs and play a role on asymptomatic HIVE mechanism. Despite the fact that action of ARVs in the CNS, except for DRV/r, was far below, the role of drug exposure and activity in CSF on HIVE pathogenesis remains controversial.....It is debated whether HIV cerebrospinal fluid (CSF) escape (HIVE) may be linked to patients' features or to ineffective antiretroviral (ARV)CSF penetration. Aim was to assess CSF penetration and activity of ARVs and correlation with bloodbrainbarrier (BBB) dysfunction and to estimate risk and predictors of HIVE."
Reported by Jules Levin
CROI 2017 Feb 14-16 Seattle, WA
Pinnetti C1, Tempestilli M1, Lorenzini P1, Fedele V1, Carta S1, Mazzotta V1, Agrati C1, Ammassari A1, Perno CF1,Antinori A1.
1National Institute for Infectious Diseases"Lazzaro Spallanzani", IRCCS, Rome, Italy
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Blood-Brain Barrier Permeability and Neurocognitive Performance in HIV+
Adults http://www.natap.org/2016/AGE/AGE_23.htm
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