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Persistent Immune Activation Despite ART: The "Die is Cast" Before ART Initiation
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"Suggests "the die is cast": immunologic and virologic effects occurring before ART initiation have long-lasting effects despite sustained virologic suppression
.....Interventions that reduce inflammation or activation may have limited effects on HIV persistence
.....Need to understand host & viral factors that affect virologic, immunologic and inflammatory "set points" on ART"
Reported by Jules Levin
CROI 2017 Feb 14-17 Seattle, WA
Rajesh Gandhi1, Deborah McMahon2, Ronald Bosch3, Christina M. Lalama3, Bernard Macatangay2, Joshua Cyktor2, Ann Collier4, Charles Rinaldo2, Joseph J. Eron5, John W. Mellors2 on behalf of the ACTG A5321 Team
1Massachusetts General Hosp, Boston, MA, USA; 2Univ of Pittsburgh, Pittsburgh, PA, USA; 3Harvard Chan Sch of PH, Boston, MA, USA; 4Univ of Washington, Seattle, WA, USA; 5Univ of North Carolina at Chapel Hill, Chapel Hill, NC, USA
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