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Acetyl-CoA Carboxylase Inhibitor GS-0976 Leads to Suppression of Hepatic De Novo Lipogenesis and Significant Improvements in MRI-PDFF, MRE and Markers of Fibrosis after 12 Weeks of Therapy in Patients with NASH
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Reported by Jules Levin
EASL 2017 April 19-23 Amsterdam Netherlands
Eric J. Lawitz,1 Fred Poordad,1 Angie Coste,1 Nicole Loo,1 C. Stephen Djedjos,2 Bryan McColgan,2 Catherine Jia,2 Ren Xu,2 Robert P. Myers,2 G. Mani Subramanian,2 John G. McHutchison,2 Michael S. Middleton,3 Claude Sirlin,3 Edna Nyangau,4 Mark Fitch,4 Kelvin Li,4 Marc Hellerstein4
1Texas Liver Institute, University of Texas Health, San Antonio, TX, USA
2Gilead Sciences, Inc., Foster City, CA, USA
3University of California at San Diego, San Diego, CA, USA
4University of California Berkeley, Berkeley, CA, USA
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