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Hepatic targeted RNA interference provides deep
and prolonged knockdown
of alpha-1
antitrypsin
levels in ZZ patients
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Reported by Jules Levin
EASL 2017 April 19-23 Amsterdam Netherlands
Alice Turner1, Jan Stolk2, Robert Bals3, Jason Lickliter4, James
Hamilton5, Dawn R Christianson5, Bruce D Given5, Jonathan G Burdon6,
Rohit Loomba7, James K Stoller8, Jeffery H Teckman9
1University of Birmingham, Birmingham, UK, 2Leiden University Medical Center, Leiden, The Netherlands, 3Saarland University Hospital, Homburg, Germany, 4Nucleus Network, Melbourne, Victoria, Australia, 5Arrowhead Pharmaceuticals, Pasadena, CA, USA, 6Saint Vincent's Hospital, Melbourne, Australia, 7University of California at San Diego, San Diego, CA. USA, 8Cleveland Clinic, Cleveland, OH. USA, 9St. Louis University School of Medicine, St. Louis, MO. USA
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