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Lack of Clinically Relevant Effect of Bictegravir on
Metformin Pharmacokinetics and Pharmacodynamics
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Reported by Jules Levin
18th International Workshop on Clinical Pharmacology of Antiviral Therapy, June 14-16, 2017, Chicago, IL
Heather Zhang, Steve K. West, Amanda Vu, Hal Martin, Hiba Graham, Erin Quirk, Brian P. Kearney, Joseph M. Custodio
Gilead Sciences, Inc., Foster City, California, USA
References
1. Gallant M, et al. J Acquir Immune Defic Syndr 2017;75:61-6; 2. Sax P, et al. Lancet HIV 2017;4:e154-60; 3. Zhang H, et al. CROI 2017, abstr 40; 4. Glucophage [package insert]. Princeton, NJ: Bristol-Myers Squibb Company, 4/2017; 5. Gong L, et al. Pharmacogenet Genomics 2012;22:820-7;
6. Graham GG, et al. Clin Pharmacokinet 2011;50:81-98; 7. Song IH, et al. J Acquir Immune Defic Syndr 2016;72:400-7; 8. Zack J, et al. Clin Pharmacol Drug Dev 2015;4:121-9; 9. Oh J, et al. Diabetes Obes Metab 2016;18:104-8; 10. Zhang L, et al. ASCPT 2015, Science at Sunrise, March 7.
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