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ASK1 Inhibition Reduces Progression of Liver Cirrhosis and Prevents Tumor Development in the BALB/c.Mdr2-/- Mouse Model of Biliary Fibrosis
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Reported by Jules Levin
AASLD: The Liver Meeting® 2018, November 9-13, 2018, San Francisco, CA
Guangyan Wei,1,2 Ping An,1 Yi Lin,1 Kahini Vaid,1 Grant Budas,3 Amanda Mikels-Vigdal,3 Ming Kuang,2 Yury Popov1
1Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; 2The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 3Gilead Sciences, Inc., Foster City, CA
References: 1. Ichijo H, et al. Science 1997;275:90-4; 2. Schuster S, et al. Nat Rev Gastroenterol Hepatol 2017;14:329-30; 3. Wang P, et al. Nat Medicine 2017;23:439-49; 4. Yamamoto E, et al. Hypertension 2008;52:573-80; 5. Loomba R, et al. Hepatology 2018;67:549-59; 6. Ikenega N, et al. Am J Pathol 2015;185:325-34.
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