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HIV-1 VIRAL REBOUND AND SAFETY OUTCOMES OF POSTPARTUM
TREATMENT INTERRUPTION IN WOMEN
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Reported by Jules Levin
CROI 2018 March 4-7 Boston MA
Catherine N. Le1, Paula Britto2, Sean S. Brummel2, Risa M. Hoffman1, Patricia M. Flynn3, Taha E. Taha4, Anne Coletti5, Mary Glenn Fowler6, Karin Klingman7, James A. McIntyre8,9, Jonathan Z. Li10, Judith S. Currier1
1University of California Los Angeles, Los Angeles, CA, USA, 2Harvard T.H Chan School of Public Health, Boston, USA, 3St. Jude Children's Research Hospital, Memphis, TN, USA, 4Johns Hopkins Bloomberg School of Public Health, Boston, MA, USA, 5FHI 360, Durham, NC, USA,
6Johns Hopkins U. School of Medicine, Baltimore, MD, USA, 7DAIDS, NIAID, Bethesda, MD, USA, 8Anova Health Institute, Johannesburg, South Africa, 9School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa, 10Brigham and Women's Hospital, Boston, MA, USA
REFERENCES
1. Strategies for Management of Antiretroviral Therapy (SMART) Study Group. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med. 2006;2006(355):2283-2296.
2. Danel C, Moh R, Minga A, et al. CD4-guided structured antiretroviral treatment interruption strategy in HIV-infected adults in west Africa (Trivacan ANRS 1269 trial): a randomised trial. The Lancet.
2006;367(9527):1981-1989. doi:10.1016/S0140-6736(06)68887-9
3. Henrich TJ, Hanhauser E, Marty FM, et al. Antiretroviral-Free HIV-1 Remission and Viral Rebound Following Allogeneic Stem Cell Transplantation: A Report of Two Cases. Ann Intern Med. 2014;161(5):319-327. doi:10.7326/M14-1027
4. Rothenberger MK, Keele BF, Wietgrefe SW, et al. Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption. Proc Natl Acad Sci.
2015;112(10):E1126-E1134. doi:10.1073/pnas.1414926112
5. Joint United Nations Programme on HIV/AIDS. Global AIDS update 2016. Geneva UNAIDS. 2016.
6. Johnston RE, Heitzeg MM. Sex, Age, Race and Intervention Type in Clinical Studies of HIV Cure: A Systematic Review. AIDS Res Hum Retroviruses. 2014;31(1):85-97. doi:10.1089/aid.2014.0205
7. Fowler MG, Qin M, Fiscus SA, et al. Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention. N Engl J Med. 2016;375(18):1726-1737. doi:10.1056/NEJMoa1511691
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