icon-folder.gif   Conference Reports for NATAP  
 
  Glasgow HIV
28 - 31 October 2018
Glasgow, UK
Back grey_arrow_rt.gif
 
 
 
HIV and Cancer Curative Approaches Cross-disciplinary research
 
 
  Steven Deeks, MD
Professor of Medicine
University of California, San Francisco
 
Reported by Jules Levin
Glasgow Oct 27-31 2018
 
Glasgow Oct 27-31 2018

1109181

1109182

1109183

1109184

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002417
 
Conclusions
 
We report HIV relapse despite initiation of ART at one of the earliest stages of acute HIV infection possible. Near complete or complete loss of detectable HIV in blood and tissues did not lead to indefinite ART-free HIV remission. However, the small numbers of latently infected cells in individuals treated during hyperacute infection may be associated with prolonged ART-free remission.
 
What did the researchers find?
 
°No HIV could be definitively detected for up to 2 years in the participant who initiated ART approximately 10 days after HIV infection.
 
°Intermittent, very low levels of HIV were detected in blood but not tissue in the participant who initiated ART an estimated 12 days following infection.
 
°The participant with no detectable HIV following ART experienced viral rebound 225 days after stopping ART.
 
What do these findings mean?
 
°HIV relapsed despite initiation of ART at one of the earliest stages of acute HIV infection possible.
 
°Near complete loss of detectable HIV in blood and tissues did not lead to indefinite ART-free HIV remission.
 
-----------------------

1109185

1109186

1109187

1109189

11091810