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"Increased risk of both mortality and incident comorbidity among frail HIV-positive and HIV-negative participants and increased risk of frailty progression in those with HIV."
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Reported by Jules Levin
22nd International AIDS Conference, Amsterdam, Netherlands, July 23-27, 2018
The AGEhIV Cohort Study,
Eveline Verheij
Frailty was a strong predictor of mortality and incident comorbidity, regardless of HIV-status. Frailty was more prevalent among HIV-positive individuals and HIV-status was associated with frailty progression, which was partly mediated by a higher waist-to-hip ratio, pre-existing comorbidity burden and depression. These results provide guidance to clinicians in recognizing patients at risk for developing frailty and associated adverse health outcomes, and illustrate the importance of maintaining physical and mental health.
Associated by HIV status, appeared to be mediated by whr [waist-hep ratio], pre/existing comorb.
Depressive symp is correlated with the frailtyscore, in our analysis we are likely overemphasizing the effect of depression on progression to frailty.
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