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Comparison of depression and anxiety
between HIV-positive and HIV-negative people....
3-7 Times Higher Rates for HIV+/Aging Increases Rates
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HIV+ have 3-7 Times Greater Depression & Anxiety vs HIV-neg, which increases with age & length of time with HIV....Authors conclude: "these results further evidence that living with HIV has a considerable adverse impact on mental health.... may reflect psychological, socio-economic or biological effects of ageing with HIV"
from Jules: in this 6000 person large study across 8 HIV clinics in London/UK comparing HIV+ to HIV-neg.......of note Prevalences of mental health measures for HIV-positive versus HIV-negative were: 27.0% versus 10.5% for depressive symptoms; 21.6% versus 9.6% for anxiety symptoms ; 34.6% versus 16.2% for depression overall. - rates of depression & anxiety are 3-4 times greater for HIV+ regardless of viral suppression (<50 or >50): and increased substantially with longer time since HIV diagnosis. Those HIV+ having HIV for short time 2-5 years had lower rates of around 2-3 times that of HIV-neg but rates increased with time since HIV diagnosis and for those HIV+ for 15-20 years rates were 4-7 times greater. Authors conclude: "these results further evidence that living with HIV has a considerable adverse impact on mental health.... may reflect psychological, socio-economic or biological effects of ageing with HIV".....In addition to HIV-status, younger age, being MSM or female, and lower education level were independently associated with poorer mental health, but ethnicity was not. For example, for depression overall, aORs (95% CI) were: 2.1 (1.4, 3.3), 1.4 (1.0, 2.0), 1.9 (1.3, 2.7), 1.9 (1.3,2.8) for <30, 30-39, 40-49, 50-59 vs 60-69 years; 1.6 (1.2, 2.1) and 1.5 (1.1, 2.0) for MSM and women vs heterosexual men; 1.9 (1.7, 2.2) for non-university education; 1.0 (0.8, 1,4), 1.0 (0.7, 1.5), 1.0 (0.7, 1.3) for Black Africa, Black other, other versus white. Associations were broadly similar by HIV-status (interactions, p≥0.1).
AUTHOR CONCLUSIONS: These results give further evidence that living with HIV has a considerable adverse impact on mental health. The higher prevalence of depression and anxiety among people with HIV was evident across ART/VL categories, including among those with viral suppression on ART. Higher prevalence of depression and anxiety was also evident among those recently diagnosed, but longer time since diagnosis appeared to be a crucial additional factor. This may reflect poorer HIV prognosis in earlier years and/or psychological, socio-economic or biological effects of ageing with HIV.
Reported by Jules Levin
22nd International AIDS Conference (AIDS 2018), Amsterdam, Netherlands, 23-27 July 2018
Fiona Lampe1, Alec Miners2, Noemi Kreif3, Ada Miltz1, Andrew Phillips1, Janey Sewell1, Lorraine Sherr1, Jane Anderson4, Richard Gilson1, Rebecca O'Connell5, Amanda Clarke6, Margaret Johnson7, Ed Wilkins8, Simon Collins9, Jonathon Elford10, Andrew Speakman1, Alison Rodger1, for the ASTRA and AURAH Study Groups
1University College London, London, UK; 2London School of Hygiene and Tropical Medicine, London, UK; 3University of York, York, UK; 4Homerton University Hospital NHS Foundation Trust, London, UK; 5Barts Health NHS Trust, London, UK; 6Brighton and Sussex University Hospitals NHS Trust, Brighton, UK; 7Royal Free London NHS Foundation Trust, London, UK; 8Pennine Acute Hospitals NHS Trust, Manchester, UK; 9HIV i-Base, London, UK; 10City University London, London, UK
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