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Validation of the Diagnostic Accuracy of Magnetic Resonance Elastography for the Detection of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis Across Multiple Phase 2 and 3 Clinical Trials
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AASLD 2019 Nov 8-12 Boston
Reported by Jules Levin
Rohit Loomba,1 Naim Alkhouri,2 Mazen Noureddin,3 Jie Zhang,4 Bryan J. McColgan,4 C. Stephen Djedjos,4 Robert P. Myers,4 Michael Middleton,5 Zachary Goodman,6 Kris Kowdley,7 Atsushi Nakajima,8 Stephen A. Harrison,9 Zobair Younossi,6 Eric J. Lawitz,2 Vincent Wong,10 Keyur Patel11
1NAFLD Research Center, UC San Diego School of Medicine, La Jolla, CA; 2Texas Liver Institute, UT Health San Antonio, TX; 3Cedars-Sinai, Los Angeles, CA; 4Gilead Sciences, Inc., Foster City, CA; 5Dept of Radiology, UC San Diego School of Medicine; 6Inova Fairfax Hospital, Falls Church, VA; 7Swedish Medical Center, Seattle, WA; 8Yokohama City University Graduate School of Medicine, Yokohama, Japan; 9Pinnacle Clinical Research, Austin, TX; 10Center for Liver Health, The Chinese University of Hong Kong; 11University Health Network, Toronto, Ontario, Canada
References: 1. Sudhakar K, et al. J Comput Assist Tomogr 2013;37:887-96; 2. Venkatesh SK, et al. J Magn Reson Imaging 2013;37:544-55; 3. Chen J, et al. Radiology 2011;259:749-56; 4. Loomba R, et al. Hepatology 2014;60:1920-8; 5. Yin M, et al. Clin Gastroenterol Hepatol 2007;5:1207-13; 6. Harrison SA, et al. Gastroenterology 2018;155:1140-53; 7. Loomba R, et al. Hepatology 2018;67:549-59; 8. Loomba R, et al. Gastroenterology 2018;155:1463-73; 9. Patel K, et al. AASLD 2018, abstr 736.
Acknowledgments: We extend our thanks to the patients, their families, and all participating investigators. This study was funded by Gilead Sciences, Inc.
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