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Impact of Prior Tenofovir Disoproxil Fumarate Treatment Duration on Tenofovir Alafenamide Safety Profile in Virally Suppressed, Chronic HBV Patients Switched From TDF to TAF
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AASLD November 8-12, 2019, Boston, MA
Reported by Jules Levin
Henry L.Y. Chan,1 Pietro Lampertico,2 Sang Hoon Ahn,3 Scott Fung,4 Ho Bae,5 Alnoor Ramji,6 June Sung Lee,7 Stephen Shafran,8 Stuart C. Gordon,9 Charles Phan,10 Susanna Tan,11 John F. Flaherty,11 Anuj Gaggar,11 George Wu,11 Vithika Suri,11 Daryl Lau,12 Kwan Soo Byun,13 Kosh Agarwal,14 Young-Suk Lim,15 Maria Buti16
1The Chinese University of Hong Kong; 2Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Italy; 3Yonsei University College of Medicine, Seoul, Republic of Korea; 4Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; 5Asian Pacific Liver Center, St. Vincent Medical Center, Los Angeles, CA; 6The University of British Columbia, Vancouver, Canada; 7Inje University College of Medicine, Busan, Republic of Korea; 8University of Alberta, Edmonton, Canada; 9 Henry Ford Health System, Detroit, MI; 10Greater Houston Gastroenterology, Sugar Land, TX; 11Gilead Sciences, Inc., Foster City, CA; 12Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 13Korea University Guro Hospital, Seoul; 14Institute of Liver Studies, King's College Hospital, London, UK; 15Asan Medical Center, University of Ulsan College of Medicine, Seoul; 16Centro de Investigacion Biomedica en Red de Enfermedades Hepáticas y Digestivas, Hospital Universitari Valle Hebron, Barcelona, Spain
References: 1. Babusis D, et al. Mol Pharm 2013;10:459-66; 2. Lee WA, et al. Antimicrob Agents Chemother 2005;49:1898-906; 3. Murakami E, et al. Antimicrob Agents Chemother 2015;59:3563-9; 4. Agarwal K, et al. J Hepatol 2015;62:533-40; 5. Lampertico P, et al. EASL 2019, poster FRI-183; 6. Terrault NA, et al. Hepatology 2018;67:1560-99.
Acknowledgments: We extend our thanks to the patients, their families, and all participating investigators. This study was funded by Gilead Sciences, Inc.
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