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Dolutegravir and Insulin Resistance
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Reported by Jules Levin
CROI 2019 March 4-7 Seattle
Janet Lo,1 James Oyee,2 Melissa Crawford,2 Richard Grove,2 Ralph DeMasi,3 Lloyd Curtis,2 Anna Fettiplace,2 Vani Vannappagari,3 Nassrin Payvandi,4 Michael Aboud,4 Jean van Wyk4
1Massachusetts General Hospital and Harvard Medical School, Boston, MA; 2GlaxoSmithKline, Uxbridge, Middlesex, UK; 3ViiV Healthcare, Research Triangle Park, NC; 4ViiV Healthcare, Brentford, UK
The normal HOMA-IR value of healthy human ranges from 1.7-2.0
Optimal Range: 1.0 (0.5-1.4)
• Less than 1.0 means you are insulin-sensitive which is optimal.
• Above 1.9 indicates early insulin resistance.
• Above 2.9 indicates significant insulin resistance.
HOMA-IR stands for Homeostatic Model Assessment of Insulin Resistance. The meaningful part of the acronym is the IR “Insulin Resistance” part. This calculation marks for both the presence and extent of any insulin resistance that you might currently express. You can visit TheBloodCode.com to plug in your values and get the calculation. It is a terrific way to reveal the dynamic between your baseline (fasting) blood sugar and the responsive hormone insulin.
Low HOMA-IR means that you are sensitive to insulin. A small amount of the hormone insulin is doing the trick to keep your blood sugars in good balance.
High HOMA-IR relates to your level of insulin resistance. The higher the number, the more resistant you are to the message of insulin. If you are above 2, your self-prescribed diet and fitness habits will bring your number down into the lower insulin-sensitive range.[i]
https://www.thebloodcode.com/homa-ir-know/
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