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A Combination of the ACC Inhibitor GS-0976 (firsocostat) and the Nonsteroidal FXR Agonist GS-9674 (cilofexor)
Improves Hepatic Steatosis, Biochemistry, and Stiffness in Patients With Nonalcoholic Steatohepatitis
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Reported by Jules Levin
EASL 2019 April 10-14 Vienna
References: 1. Marra F, Svegliati-Baroni G. J Hepatol 2018;68:280-95; 2. Bates J, et al. AASLD 2017, abstr 425; 3. Bates J, et al. EASL 2018, abstr 3755; 4. Liles J, et al. EASL 2017, abstr PS-030; 5. Loomba R, et al. Gastroenterology 2018;155:1463-73; 6. Patel K, et al. AASLD 2018, abstr 736; 7. Lawitz EJ, et al. Clin Gastroenterol Hepatol 2018;16:1983-91; 8. Harrison S, et al. EASL 2018, abstr FRI-487; 9. Decaris ML, et al. PloS One 2015;10:e0123311; 10. Decaris ML, et al. Hepatology 2017;65:78-88; 11. Hellerstein MK, et al. Am J Physiol 1999:276:E1146-70.
Acknowledgments: We extend our thanks to the patients and their families who participated in this study. This study was funded by Gilead Sciences, Inc.
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