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Increasing Cognitive Aging in HIV+ WIHS Women Despite Viral Suppression, MACS Men
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AGE: Cognitive aging in the era of effective antiretrovirals - (09/19/18)
WIHS Women Study: at CROI 2017 & published - Cognitive trajectories over 4 years among HIV-infected women with optimal viral suppression: HIV+ virally suppressed had worse cognitive decline in 3 domains vs HIV-neg, 4 yrs followup
published study: http://www.natap.org/2018/HIV/012918_01.htm
"Overall, global function, learning, memory, attention/working memory, and fluency continue to be vulnerabilities among HIV+ women, particularly among those who are virally suppressed. Future longer-term studies are needed to confirm these observed patterns and to investigate the neurobiological mechanisms underlying these findings."
"Cognitive difficulties remain among HIV+ women despite persistent viral suppression....Unexpectedly, VS women had worse scores in attention and fluency when performance was measured continuously compared to NVS women [no consistent viral suppression].....Although the underlying factors driving this pattern of results are unclear, it is possible that cART itself contributes to brain injury, perhaps through mitochondrial injury
CROI: I Keep Forgetting HIV, Aging, and Cognitive Disorders.....http://www.natap.org/2019/CROI/croi_157.htm......"Due to advancing age of people living with HIV, the likelihood for Alzheimer's disease will increase......
AGE: Cognitive aging in the era of effective antiretrovirals - (09/19/18)
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