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LONG-TERM DTG+3TC SWITCH EFFICACY IN PATIENTS WITH ARCHIVED 3TC RESISTANCE
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CROI 2020
Reported by Jules Levin
Rosa de Miguel1, David Rial2, Lourdes Domínguez-Domínguez2, Rocio Montejano1, Andrés Esteban-Cantos1, Otilia Bisbal2, Natalia Stella-Ascariz1, Paula Aranguren2, Mónica García-Álvarez2, Belen Alejos3, Maria Lagarde2,
Jose I. Bernardino1, Federico Pulido2, Jose R. Arribas1, for the ART-PRO, PI16/00837-PI16/00678 study group
1 Hospital La Paz Institute for Health Research, Madrid, Spain. 2 Hospital Universitario 12 de Octubre, Madrid, Spain. 3 Institute of Health Carlos III, Madrid, Spain.
HYPERMUTATION ANALYSIS: 16/27 of samples with 3TC resistance-associated mutations (RAMs) detected through NGS (>1% threshold) had retrotranscriptase defective viral genomes due to APOBEC-induced mutations.
After removal of reads identified as hypermutated (18.5%), 3TC RAMs remained present in 22/27 samples.
TRANSIENT VIRAL REBOUNDS: 14 transient virals rebounds in 12 participants (6 in the group with historical 3TC-resistance). No virologic failures.
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