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TRICARBOXYLIC ACID METABOLITES PREDICT METABOLIC COMORBIDITIES AND DEATH IN AGING PWH
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CROI 2020
Reported by Jules Levin
These associations implicate metabolic remodeling in the pathogenesis of age-associated comorbidities among PWH.
from Jules: AS I have said before HIV is a disease of metabolics in that it disrupts normal metabolics in otherwise HIV-uninfected healthy people & in HIV+ causes all these aberrations that lead to increased risk in various conditions & comorbidities. This study looks at physical comorbidities but DOES NOT look at mental commodities like depression, anxiety etc.
Corrilynn O. Hileman1,2, Sausan Azzam2, Daniela Schlatzer2,Kunling Wu3, Katherine Tassiopoulos3, Roger Bedimo4, Ronald J. Ellis5, Kristine M. Erlandson6, Asha Kallianpur2,7, Susan L. Koletar8, Alan L. Landay9, Frank J. Palella10, MuralidharPallaki2,11, BabafemiTaiwo10, Charles L. Hoppel2, and Robert Kalayjian1,2,11for the HIV Infection, Aging, and Immune Function Long-Term Observational Study (HAILO) (ACTG A5322) Research Team
1MetroHealth Medical Center, Cleveland, OH, 2Case Western Reserve University School of Medicine, Cleveland, OH, 3Harvard T.H. Chan School of Public Health, Boston, MA, 4Trinity Health and Wellness Center, Dallas, TX, 5University of California, San Diego, CA, 6University of Colorado Anschutz Medical Campus, Aurora, CO, 7Cleveland Clinic Lerner Research Institute, Cleveland, OH, 8The Ohio State University, Columbus, OH, 9Rush University Medical Center, Chicago, IL, 10Northwestern University Feinberg School of Medicine, Chicago, IL, 11Cleveland Veterans Administration Medical Center, Cleveland, OH
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