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Removal of Fibrosis-Related Genes Identifies a Hepatic Gene Expression Signature That Identifies Canonical
Signaling Pathways and Is Correlated With Clinical Outcomes in Patients With Primary Sclerosing Cholangitis
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EASL 2020 Aug 27-29 virtual
Reported by Jules Levin
Michael Trauner,1 Yevgeniy Gindin,2 Jing Zhu Zhou,2 Ryan Huss,2 Chuhan Chung,2 G. Mani Subramanian,2 Robert P. Myers,2 Zachary Goodman,3 Christopher L. Bowlus,4 Cynthia Levy,5 Andrew J. Muir,6 Michael Manns7
1Medical University of Vienna, Austria; 2Gilead Sciences, Inc., Foster City, California, USA; 3Inova Fairfax Hospital, Falls Church, Virginia, USA; 4University of California, Davis; 5University of Miami, Coral Gables, Florida, USA; 6Duke University School of Medicine, Durham, North Carolina, USA; 7Medizinische Hochschule Hannover, Germany
References: 1. Folseraas T, et al. J Hepatol 2012;57:366-75; 2. Karlsen T, et al. Gastroenterology 2010;138:1102-11; 3. Muir AJ, et al. Hepatology 2019;69:684-98; 4. Patro R, et al. Nat Methods 2017;14:417-9; 5. McCarthy DJ, et al. Nucleic Acids Res 2012;40:4288-97.
Acknowledgments: We extend our thanks to the patients and their families. This study was funded by Gilead Sciences, Inc.
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