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Safety and Efficacy of Tenofovir Alafenamide in Geriatric Patients With Chronic Hepatitis B: Experience From 4 Ongoing Phase 2 and Phase 3 Clinical Trials
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EASL 2020 Aug 27-29 virtual
Reported by Jules Levin
Scott Fung,1 Maurizia Brunetto,2 Maria Buti,3 Pietro Lampertico,4 Kosh Agarwal,5 Wan-Long Chuang,6 Namiki Izumi,7 Mandana Khalili,8 Alnoor Ramji,9 Ho Bae,10 Xiaoli Ma,11 Shuyuan Mo,12 John F. Flaherty,12 Anuj Gaggar,12 Vithika Suri,12 Susanna K. Tan,12 Mani Subramanian,12 Calvin Q. Pan,13 Patrick Marcellin,14 Harry L.A. Janssen,15 Edward Gane,16 Henry L.Y. Chan17
1University of Toronto, Ontario, Canada; 2Azienda Ospedaliero Universitaria Pisana, Pisa, Italy; 3Hospital Universitari Vall d'Hebron, Barcelona, Spain; 4Centro di Riferimento per la Diagnosi e lo Studio delle Malattie del Fegato e delle Vie Biliari "Angela Maria ed Antonio Migliavacca," Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Italy; 5Institute of Liver Studies, King's College Hospital NHS Trust, London, UK; 6Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Taiwan; 7Japanese Red Cross Musashino Hospital, Musashino, Japan; 8University of California San Francisco, USA; 9The University of British Columbia, Vancouver, Canada; 10Asian Pacific Liver Center, St. Vincent Medical Center, Los Angeles, California; 11Xiaoli Ma, PC, Bryn Mawr, Pennsylvania, USA; 12Gilead Sciences, Inc., Foster City, California; 13NYU Langone Medical Center, New York, New York, USA; 14Hôpital Beaujon AP-HP, Clichy, France; 15Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto; 16Auckland Clinical Studies, Auckland, New Zealand; 17Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong
References: 1. Agarwal K, et al. J Hepatol 2018;68:672-81; 2. Buti M, et al. Lancet Gastroenterol Hepatol 2016;1:196-206; 3. Chan HLY, et al. Lancet Gastroenterol Hepatol 2016;1:185-95; 4. Lampertico P, et al. The Digital International Liver Congress 2020, oral SAT091; 5. Nguyen MH, et al. Hepatology 2019;69:959-73; 6. EASL. J Hepatol 2017;67:370-98; 7. Terrault NA, et al. Hepatology 2018;67:1560-99; 8. Janssen H, et al. The Digital International Liver Congress 2020, poster SAT429; 9. Lim Y-S, et al. The Digital International Liver Congress 2020, poster SAT442.
Acknowledgments: We extend our thanks to the patients, their families, and all participating investigators. These studies were funded by Gilead Sciences, Inc.
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