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Safety and Efficacy of Switching to Tenofovir Alafenamide in Virally Suppressed Chronic
Hepatitis B Patients With Hepatic Impairment: Week-48 Results From a Phase 2 Open-label Study
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EASL 2020 Aug 27-29 virtual
Reported by Jules Levin
Young-Suk Lim,1 Chun-Yen Lin,2 Jeong Heo,3 Ho Bae,4 Wan-Long Chuang,5 Aric Josun Hui,6 Magdy Elkhashab,7 Huy Trinh,8 Susanna K. Tan,9 Shuyuan Mo,9 John F. Flaherty,9 Vithika Suri,9 Anuj Gaggar,9 Mani Subramanian,9 Tak Yin Owen Tsang,10 Stephen Ryder,11 Pietro Andreone,12 Harry L.A. Janssen13
1Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; 2Chang Gung University College of Medicine, Taoyuan City, Taiwan; 3Pusan National University School of Medicine, Pusan National University Hospital, Busan, South Korea; 4Asian Pacific Liver Center, St. Vincent Medical Center, Los Angeles, California, USA; 5Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Taiwan; 6Alice Ho Miu Ling Nethersole Hospital, Hong Kong; 7Toronto Liver Centre, Toronto, Ontario, Canada; 8San Jose Gastroenterology, San Jose, California; 9Gilead Sciences, Inc., Foster City, California; 10Princess Margaret Hospital, Hong Kong; 11NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK; 12Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università degli Studi di Modena e Reggio Emilia, Modena, Italy; 13Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto
References: 1. Agarwal K, et al. J Hepatol 2015;62:533-40; 2. Babusis D, et al. Mol Pharm 2013;10:459-66; 3. Lee WA, et al. Antimicrob Agents Chemother 2005;49:1898-906; 4. Murakami E, et al. Antimicrob Agents Chemother 2015;59:3563-9; 5. Lampertico P, et al. The Digital International Liver Congress 2020, oral SAT091; 6. Lampertico P, et al. Lancet Gastroenterol Hepatol 2020;5:441-53; 7. Lim Y-S, et al. AASLD 2019, poster 501.
Acknowledgments: We extend our thanks to the patients, their families, and all participating investigators. This study was funded by Gilead Sciences, Inc.
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