| |
Disparate Impact of HIV/Aging on women
|
| |
| |
Here are 8 studies reporting worse physical function & mental, emotional function and decline in older aging vs men, WIHS study showed worse cognitive function. ATHENA study showed more comorbidities when <50 & worse affects on death rates for women with multiple comorbidities. Talk at Aging Wk below link suggests earlier menopause onset in HIV+ women contributes. Inflammation & biologic functioning may also contribute, childhood abuse & other life trauma contribute. Food insecurity is bad among WIHS women, viral suppression my be worse among WIHS women. Jules
1-
WIHS HIV+ Women - More falls, comorbidities, cognitive impairment, isolation/loneliness, self-stigma, detectable viral load; CDC Viral Suppression is Over Estimated in the USA; maybe more likely to have detectable viral load
"Fracture rates were higher among HIV+ than HIV- women. Cocaine and injection drug use were also significant predictors of incident fracture" " of note age matters, every 10-year increase in age increased risk for fracture in HIV+ women by 25%
http://www.natap.org/2015/CROI/croi_54.htm
2-
25% of HIV+ middle aged women in WIHS (36-48) experienced 2+ falls; 19% of HIV+ w0men had falls
CROI: LONGITUDINAL VIRAL TRAJECTORY [and Comorbidities] AMONG WOMEN IN THE WOMEN'S INTERAGENCY HIV STUDY - (02/26/17)
....20% are on HAART, 39% on ART & 30.47% of women on HAART & 38% on ART are reported here to have undetectable viral load..........5% to 11% have AIDS-associated cancer malignancies which doubled if detectable viral load, 13-15% had Non-AIDS associated cancer malignancies, 64-73% have risk factors for cardiovascular disease, 11-15% have CVD, 20% with HCV, death rate 14-30% which doubled with detectable viral load / AIDS cancer malignancies associated with detectable VL
3-
HIV+ women had significantly higher incidence rate of any fracture compared with HIV- women - 30% higher risk
4 -
Food Insecurity and Frailty among Women Living with or At-risk for HIV in the U.S. - 40% WIHS Women Have Food Insecurity
Food insecurity is defined as the limited or uncertain availability of nutritionally adequate, safe foods, or the inability to acquire personally acceptable food in socially acceptable ways [1]. Food insecurity affects about a quarter to half of HIV-infected adults in the United States (U.S.) compared to 14% of the general population [2, 3]. Food insecurity is associated with lower physical health status, incomplete viral load suppression, and lower CD4+ counts [2, 4, 5].
The prevalence of WIHS participants with very low food security (12%) is more than twice as high as the prevalence of households in the U.S. general population with very low food security (5%) [10]. Participants had a mean age of 49 (standard deviation (SD): 8.6). The sample was predominantly non-Hispanic African- American (67%); 18% were Hispanic, 11% were non-Hispanic white, and 3.7% identified as other (Supplementary Table I).
5 -
Multimorbidity and risk of death differs by gender in people living with HIV in the Netherlands - the ATHENA cohort study
women have more comorbidities & worse mortality - death rates
6 -
Physical function worse in older women than men with HIV, despite better CD4 recovery - (09/19/18)
Older women with HIV had significantly worse physical function and quality of life than older men, according to analysis of 1126 people in the Modena HIV cohort
Women reported more exhaustion. Exhaustion (rarely: <1day/week) was reported by 56% of women vs 68% of men. BUT, exhaustion 1-2d/week was reported by 33% of women vs 25% of men. Exhaustion 3-4 d/week was reported by 9% of women vs 5.8% of men. Always or almost always exhaustion (5-7 d/week was reported by 3 women (1.1%) and 2 men (0.2%). see table below.
7 -
women in WIHS have worse cognitive function
AGE: Cognitive aging in the era of effective antiretrovirals - (09/19/18)
Females were at a 56% greater risk for a fall.
8 -
Medicare in PLWH vs HIV- found women with HV had higher rates of certain of these comorbidities than HIV+ men....including hypertension, depression, anxiety, ostearthritis, osteoporosis
http://www.natap.org/2019/HIV/090419_06.htm
|
|
| |
| |
|
|
|
