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Correlation between inflammatory biomarkers with four cardiovascular disease (CVD) risk models in aging patients living with HIV
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EACS 2021 Oct 27-30
G. Dragovic1, K. Al Musalhi2, I. Soldatovic3,. Jevtovic4, B. Dimitrijevic1, D. Nair2
1School of Medicine; University of Belgrade, Department of Pharmacology, Clinical Pharmacology and Toxicology, Belgrade, Serbia, 2Royal Free Hospital and University College London, Department of Clinical Biochemistry, London, United Kingdom, 3School of Medicine; University of Belgrade, Institute for Biomedical Statistics, Belgrade, Serbia, 4School of Medicine; University of Belgrade, Infectious and Tropical Diseases Hospital, Belgrade, Serbia
Purpose or Objective
The aim of this study was to evaluate the possible correlations between inflammatory biomarkers: interleukins (IL-4, IL-6, IL-10), interferon-gamma (IFN-γ) and high-sensitivity C-reactive protein (hsCRP) with four cardiovascular disease (CVD) risk models in HIV-infected patients.
Results
A cross-sectional analysis of 87 HIV-infected consecutive patients, all males, between 50 and 81 years old who had received combined antiretroviral therapy (cART) for at least 48 months was performed. The following four CVD risk models: the Framingham risk score (FRS), European Systematic Coronary Risk Evaluation Score (SCORE), the Data Collection on Adverse Effects of Anti-HIV Drugs study (DAD) and the Pooled Cohort Atherosclerotic CVD risk (ASCVD) equations we taken in the final analysis with following cut-offs: 10-year CVD-FRS≥20%, 10-year SCORE≥5%, 10-year ASCVD risk ≥7.5%, and DAD CVD score >5%. Association between numerical variables were explored using Spearman correlation, while all p-values less than 0.05 were considered significant.
Materials and Methods
The prevalence of current smoking was recorded in 41 (47.1%), hypertension in 54 (62.1%) and hypercholesterolemia (>6.2 mmol/L) in 36 (41.4%) patients. 39 (44.8%) were overweight, 11 (12.6%) with diabetes mellitus and 26 (29.9%) had metabolic syndrome. Correlation analysis revealed significant correlations between IL-4 and waist circumference, body mass index and IFN-γ (p=0.004, p=0.013, p=0.000, respectively); between IL-6 and patients' age, IFN-γ and hsCRP (p=0.019, p=0.005, p=0.001, respectively). While IL-10 showed correlation with IFN-γ (p=0.001). The prevalence of high CVD scores or risk equivalents was noticeable and it ranged from 32.2% for the CVD-FRS to 50.6% for the DAD score. Significant correlations was found between IL-4 and IL-6 and DAD CVD score >5% (Rho= -0.332, p=0.001; Rho=0.291, p=0.006, respectively), as well as with 10-year ASCVD risk ≥7.5% (Rho= -0.256, p=0.016; Rho=0.316, p=0.003, respectively).
Conclusion
IL-4 and IL-6 were associated with the DAD CVD score >5% and 10-year ASCVD risk ≥7.5% models in aging HIV-patients.
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