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Persistent long-term risk of liver related complications in HCV patients after antiviral therapy - Data from the German Hepatitis C-Registry
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EASL 2021 June 23-26
Heiner Wedemeyer1,2, Peter Buggisch3, Stefan Mauss4, Albrecht Stoehr3, Hartwig Klinker5, Klaus HW Boeker6, Gerlinde Teuber7, Yvonne Serfert2, Markus
Cornberg1,8, Heinz Hartmann2, Dietrich Huppe9, Christoph Sarrazin10,11, Karl-Georg Simon12, Stefan Zeuzem11, Thomas Berg13, German Hepatitis C-Registry7
1Hannover Medical School, Hannover, Germany; 2Leberstiftungs-GmbH Deutschland, Hannover, Germany; 3ifi-Institute for Interdisciplinary Medicine, Hamburg, Germany; 4Center for HIV and Hepatogastroenterology, Dusseldorf, Germany; 5University Hospital Wurzburg, Wurzburg, Germany; 6Center of Hepatology, Hannover, Germany; 7Practice PD Dr. med. G. Teuber, Frankfurt, Germany; 8Centre for Individualised Infection Medicine (CIIM), Hannover, Germany; 9Gastroenterologische Gemeinschaftspraxis Herne, Herne, Germany; 10St. Josefs-Hospital, Wiesbaden, Germany; 11Goethe University Hospital, Frankfurt, Germany; 12MVZ Dres. Eisenbach, Simon, Schwarz GbR, Leverkusen, Germany; 13University Hospital Leipzig, Leipzig, Germany
The overall incidence for de novo HCC was 0.6%/year. In patients with liver cirrhosis the annual HCC risk was 1.2% in the first two years after treatment and 0.8% from year 3-7. Liver cirrhosis and treatment experience were the only baseline parameters being associated with de novo HCC development with high significance (p<0.01; Table 1).
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