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Poor sleep quality in people with
HIV linked to lower CSF amyloid beta 42
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IAS 2021 July 18-22
Ronald J. Ellis1, Ahmed Chenna1, Christos J. Petropoulos1, Yolanda Lie1, Dusica Curanovic1, John Winslow1, Erin Sundermann2, David J. Moore2,
Scott L. Letendre2
1HIV Neurobehavioral Research Program, University of California, San Diego 2Monogram Biosciences, South San Francisco, CA
Abstract:
BACKGROUND: Previous studies have shown that poorer sleep quality increases the risk of Alzheimer"s Disease (AD) and that individuals with AD have both poorer sleep quality and lower levels of cerebrospinal fluid (CSF) amyloid beta 42 (Ab42) (in association with greater brain tissue amyloid deposition) than healthy elderly. These relationships have yet to be explored in people with HIV (PWH).
METHODS: Participants were ambulatory, community-dwelling PWH who had lumbar punctures to collect CSF (CSF). Sleep quality during the past month was assessed using the Pittsburgh Sleep Quality Index (PSQI) and Ab42 was measured in CSF and plasma using the Simoa platform. Pearson's correlation coefficient was calculated to assess the relationship between sleep quality and CSF Ab42.
RESULTS: Participants were 19 virally suppressed PWH, 15% female, 65% non-Hispanic white, 10% black, mean (SD) age 63.7 (8.1) years, median nadir and current CD4 136 and 541, mean SD PSQI 8.0 (4.8), PSQI > 5 = 12/19 (63%). As sleep quality became poorer, CSF Ab42 levels became lower (r = -0.491, p = 0.0278). In contrast, sleep quality was not related to Ab42 in plasma (r =-0.00973, p = 0.968). Age was not related to PSQI or CSF Ab42.
CONCLUSIONS: In this cohort of older PWH who on average had poor sleep quality, poorer sleep quality was linked to lower CSF Ab42, a pattern similar to that seen in AD. This may reflect greater amyloid aggregation and deposition in brain tissue, possibly indicating a greater risk of subsequent AD in PWH.
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