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FIBROSIS PROGRESSION RATE AMONG DIABETIC VERSUS NON- DIABETIC PATIENTS WITH BIOPSY- PROVEN NONALCOHOLIC FATTY LIVER DISEASE: A MULTICENTER PROSPECTIVE STUDY
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AASLD nov 4-8 2022
Recent studies have shown that the severity of hepatic fibrosis is the most significant independent risk factor for mortality and liver-related complications in NAFLD.(8, 9)
The researchers found that the fibrosis progression rate was significantly higher in patients with diabetes (0.17 stages) compared with those without diabetes (0.14 stages; P = 0.02).
Patients with diabetes had a higher cumulative incidence of fibrosis progression at four years compared with those without diabetes: 24 percent versus 20, 23 percent. The same was true at eight years (60 percent versus 50 percent) and 12 years (93 percent versus 76 percent). In the Cox proportional hazards model, diabetes was associated with statistically and clinically significant higher fibrosis progression (adjusted HR, 1.69; 95 percent confidence interval, 1.17 to 2.43).
AASLD: Higher Fibrosis Progression Rate in NAFLD Group With vs Without Diabetes - Mark Mascolini (11/10/22)
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