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IMPACT OF INTEGRASE STRAND TRANSFER INHIBITORS ON COGNITION IN THE HAILO COHORT
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CROI 2022 Feb 14-16
Jane A O'Halloran1, Charles W Goss1, Mansi Agarwal1, Sarah Cooley1, Kunling Wu2, Rachel Presti1, Beau Ances1, Katherine Tassiopoulos2, Kristine M Erlandson3
1Washington University School of Medicine, St Louis, Missouri, USA ; 2Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA; 3University of Colorado Denver, Aurora, Colorado, USA
It is important to understand if antiretroviral therapy (ART) changes brain function in people with HIV who are getting older. We used data from the HAILO study to see if a commonly used class of ART, the integrase inhibitor (INSTI) drug class, caused changes to overall brain function. We looked at HAILO participants who had switched their ART to an INSTI drug and had undergone testing on brain function before and after switching. Brain function was measures by a combined measure of a series of test called the NPZ4. We also looked at the individual result of each test. Overall, we saw that combined test score improved slightly overtime in people on HIV treatment and there was no worsening in the overall score after switching to INSTI therapy. The score from one of the individual tests that examines learning and memory did decrease slightly after changing to INSTIs but further research is needed to understand what this result means. Overall INSTIs do not have a clear or consistent negative affect on brain function.
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