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Role of Renin-Angiotensin-Aldosterone
System Activation in Arterial Inflammation in HIV
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"Our previous studies have demonstrated increased aldosterone during RAAS activation in PWH with increased visceral adipose tissue and also an association between VAT and LpPLA2. Here, we draw a potential relationship connecting all three variables of VAT, aldosterone, and arterial inflammation. The increased and chronic inflammation of the visceral adipose depot may be linked to cytokine production and RAAS activation and promote arterial inflammation."
CROI: IMPROVING INTESTINAL BARRIER USING GLP-2 AGONIST REDUCES ARTERIAL INFLAMMATION IN PWH - (02/16/22)
CROI 2022 Feb 11-16
Grace Shen, BS1, Teressa S. Thomas, MBBCh1, Allie R. Walpert, MSN1, Colin M. McClure, BA1, Kathleen V. Fitch, MSN1, Christopher deFilippi, MD2, Martin Torriani, MD3, Colleen G. Buckless, MS2, Gail K. Adler, MD, PhD4, Steven K. Grinspoon, MD2, Suman Srinivasa, MD2
1Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 2INOVA Heart and Vascular Institute, Falls Church, VA; 3Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 4Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
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