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IS THERE A ROLE OF NOVEL ART REGIMENS IN THE DECLINING PREVALENCE OF HAND? HAND 22% Today in Italy- Asymptomatic Remains Prevalent 10%-24%
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cd4 <500 worse; cd4 <500 worse vs cd4 >500 best; viral load >40 worse
CROI 2022 Feb 11-16
Ilaria Mastrorosa, MD
National Institute for Infectious Diseases “Lazzaro Spallanzani”, IRCCS
Rome, Italy
In 791/2,383 (33%) tests a cognitive complaint was reported and HAND prevalence was 40%, higher than among not-complaining (13%). Over the study period, a decreasing frequency of HAND was found in the entire population (Tab.1). Factors associated to HAND were older age, lower educational level, lower current CD4+count and HCV co-infection. Compared to pts receiving a NNRTI, those receiving dual and INSTI-based therapies were associated to a decreased risk of having HAND. To be tested in more recent years significantly predicted a reduced risk of HAND (Tab.2).
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