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LONG ACTING LENACAPAVIR PROTECTS AGAINST INTRAVENOUS CHALLENGE WITH SIMIAN-TROPIC HIV
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CROI 2022 Feb 11-16
Adrienne E. Swanstrom1, Bing Lu2, Kelly Wang2, Jim Zheng2, Matthew W. Breed3, Kristin E. Killoran3, Joshua Kramer3, Jorden L. Welker1, Paul D. Bieniasz4,
Theodora Hatziioannou4, Robert J. Gorelick1, Wade Blair2, Stephen R. Yant2, Jeffrey D. Lifson1, Gregory Q. Del Prete1
1AIDS and Cancer Virus Program, and 3Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA; 2Gilead Sciences, Foster City, CA, USA; 3Laboratory of Retrovirology, Rockefeller University, New York, NY, USA
References: 1. Link JO, et al. Nature 2020;584:614-8; 2. Vidal SJ, et al. Nature 2022;601:612-616; 3. Bekerman E, et al. IAS Conference on HIV Science 2021, July 18-21; 4. Yant SR, et al. Nat Med 2019;25:1377–1384; 45 Hatziioannou T, et al. Science 2014;344(6190):1401-5; 6. Schmidt F, et al. PNAS 2019;116(21):10504-10509; 7. Del Prete GQ, et al. AIDS Res Hum Retroviruses 2016;32(2):163-8. Funding: This work was funded in part by the National Cancer Institute, NIH (contract No. 75N91019D00024). The content of this poster does not necessarily reflect the view or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Study approval: All work involving research animals was conducted under a protocol approved by the Institutional Animal Care and Use Committee of the National Cancer Institute (protocol AVP-078) and adhered to the standards of the Guide for the Care and Use of Laboratory Animals in accordance with the Animal Welfare Act. Macaques were housed at the NIH and cared for in accordance with American Association for the Accreditation of Laboratory Animal Care (AAALAC) standards in an AAALAC-accredited facility (Animal Welfare Assurance number A4149-01).
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