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SARS-CoV-2 Vaccine Immunogenicity in PLWH in The Netherlands & age, CD4, HIV viral load effects
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CROI 2022 Feb 11-16
After vaccination with BNT162b2 or mRNA-1273, Anti-Spike IgG levels were lower in PLWH compared to healthy controls. In PLWH, a CD4+ T cell count <250/µL was associated with lower antibody concentration.
Kathryn S. Hensley1, Marlou J. Jongkees1, Corine H. Geurts van Kessel1, Virgil A. Dalm1, Jan G. den Hollander2, Wouter F. W. Bierman3, Eliane M. Leyten4, Emile F. Schippers5, Heidi S. Ammerlaan6, Marc Van der Valk7, Bart J.A. Rijnders1, Kees Brinkman8, Anna Roukens9, Casper Rokx1, for COVIH Study Group
1Erasmus University Medical Center, Rotterdam, 2Maasstad Hospital, Rotterdam, 3University Medical Center Groningen, Groningen, 4Haaglanden Medical Centre, The Hague, 5Haga Teaching Hospital, The Hague,
6Catharina Hospital, Eindhoven, 7DC Klinieken, Amsterdam, 8OLVG, Amsterdam, 9Leiden University Medical Center, Leiden, all in the Netherlands
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