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Reverse Inflammaging: Biological age in HCV after cure
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HCV patients had an overall significant epigenetic age acceleration (EAA) of 3.12 years at baseline compared with -1.45 years in the age- and sex-matched reference group (p<0.0003). HCV elimination resulted in a significant long-term increase in DNA methylation dominated by hypermethylated CpGs in all patient groups. Accordingly, EAA decreased to 1.37 years at long-term follow-up. The decrease in EAA was significant only between the end of treatment and follow-up (p=0.01). Interestingly, eight patients who developed hepatocellular carcinoma after SVR had the highest EAA and showed no evidence of reversal after SVR.
EASL 2022 June 22-26 London
C. Oltmanns1,2,3,4, Z. Liu1,2,4, J. Mischke1,2,3,4, M. Urbanek-Quaing1,2,3,4, J. Tauwaldt1,2,3,4,
H. Wedemeyer2,3, A. R.M. Kraft1,2,3,4, C. Xu*1,2,4,5, M. Cornberg*1,2,3,4
1 Centre for Individualized Infection Medicine (CIIM), c/o CRC Hanover, Feodor-Lynen-Str. 15, 30625 Hannover, Germany.
2 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany.
3 German Center for Infection Research, Partner-Site Hannover-Braunschweig, Hannover, Germany.
4 TWINCORE a joint venture of Helmholtz Centre for Infection Research and Hannover Medical School Hannover Germany.
5 Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525, HP, Nijmegen, the Netherlands.
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