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Women with HIV Have More Comorbidities, Worse Physical Function, & Inflammation
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women need specialized, focused care & better support & care in the clinic & support services dedicated to their needs, As well as African-Americans too & Latinos, and the aging population.
Physical function worse in older women than men with HIV, despite better CD4 recovery 55% of men & women with poor physical functioning, exhaustion, pain
HIV DIFFERENTIALLY IMPACTS AGE-RELATED COMORBIDITY BURDEN AMONG US WOMEN AND MEN
at CROI 2021
attention to this graph where you can see women >70 with HIV have almost double the rate of 5 comobidities compared to HIV-neg women >70. The same can be said for HIV+ men compared to HIV-neg men >70. But the rates of having 5 or more comorbidities were higher for HV+ women than HIV+ men over 70.
SEX MODIFIES THE ASSOCIATION BETWEEN INFLAMMATION AND VASCULAR EVENTS IN TREATED HIV
at CROI 2021
women had a 1.4-2.5 fold IQR higher inflammation - CRP, LBP, sCD14, suPAR, ICAM-1, and CMV IgG than men.
Discrete pathways of inflammation independently predict CVD and VTE [venous thromboembolism] events in treated HIV, and many of these pathways are modified by sex. As inflammation predicts CVD events more strongly in women than in men, representation of women in clinical studies of immune-based interventions in treated HIV infection is critical.
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