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Two Cases of Monkeypox-Associated Encephalomyelitis -
Colorado and the District of Columbia, July-August 2022
  Weekly / September 23, 2022
What is added by this report?
Two U.S. cases of encephalomyelitis associated with acute MPXV infection were identified during summer 2022. Whether the underlying pathophysiology resulted from direct viral neuroinvasion or a parainfectious autoimmune process is currently unknown.
Details of two cases of encephalomyelitis associated with monkeypox in previously healthy young gay men in Colorado and DC are presented in this report. The University of Colorado and Georgetown University determined that this report was not subject to human subjects review because it includes only information obtained for purposes of patient clinical care and public health outbreak response. This activity was also reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.


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