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Causes of death for persons with HIV in an integrated
healthcare system in Northern California, 2013-2017
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AIDS 2022 July 29-Aug 2 Montreal
Presenter
Kurtis Mohr
Authors
K. Mohr * (1), T. Levine-Hall (2), A. Trickey (3), J. Gill (4), J. Berenguer (5), L. Goodman (1), L. Pitts (6), M. Luu (1), J. Skarbinski (1,2), D. Satre (7,2), M. Silverberg (2)
Institutions
(1) Oakland Medical Center, Kaiser Permanente Northern California, Oakland, United States, (2) Kaiser Permanente Northern California, Division of Research, Oakland, United States, (3) University of Bristol, Population Health Sciences, Bistrol, United Kingdom, (4) University of Calgary, Southern Alberta HIV Clinic, Department of Medicine, Calgary, Canada, (5) Hospital General Universitario Gregorio Marañón, Madrid, Spain, (6) Avenue 360 Health & Wellness, Houston, United States, (7) University of California, San Francisco, Department of Psychiatry and Behavioral Sciences, San Francisco, United States
program abstract
BACKGROUND: Causes of death (COD) in persons with HIV (PWH) have shifted from a high prevalence of AIDS-related deaths to non-AIDS-related causes, including cancer and cardiovascular disease. However, death certificates inaccurately label PWH as AIDS-related when due to these other causes. The aim of this study was to evaluate the COD in PWH using the Coding Causes of Death (CoDe) methodology in HIV.
METHODS: We identified adult PWH who died between July 2013 and December 2017 while members of Kaiser Permanente Northern California (KPNC). Using abstracted data from electronic health records, we employed CoDe methodology for COD, with adjudication by two KPNC clinicians and with review of conflicting reports by an external clinician panel. We classified deaths into 12 major groups, describing distributions of COD overall, and by sex, race (Black, White, Hispanic), and HIV transmission risk (heterosexual, injection drug use [IDU], men who have sex with men [MSM]).
RESULTS: The study sample included 302 PWH with a confirmed cause of death by the State of California. Of the 302 deaths (see table), 57 (18.9%) were AIDS-related, 56 (18.5%) were cardiovascular-related, and 58 (19.2%) were cancer-related. Further analyses of COD are differentiated by sex, race, HIV transmission risk as detailed in the table.
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