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Recent French mpox cluster includes fully vaccinated patients
  News brief
April 6, 2023

Lisa Schnirring
French officials recently posted an update on an mpox cluster in the Center-Val de Loire region, with 17 cases reported since the first of the year, including 14 since March 1. All occurred in men who have sex with men who had several partners but didn't attend any common events.
Five of the patients had received two mpox vaccine doses in 2022. Also, five had received one smallpox dose during childhood, plus one dose in 2022.
Given the high proportion of vaccinated people in the cluster, 59%, Public Health France and its regional partners investigated the development, finding that the proportion of vaccinated cases is higher than the 25% observed at the national level between October and February.
"It is appropriate to await the results of real-life efficacy studies which will allow better interpretation of these data. To date, there is little perspective on the efficacy of 3rd generation vaccines against mpox infection," Public Health France said in its statement.
In other mpox developments, the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) European regional office yesterday posted a joint update on mpox, which reported 28 new cases from 7 countries since the last update 4 weeks ago. Sixteen of the cases are part of the French cluster. Six were from Spain. Other countries reporting cases are Portugal, the Netherlands, Switzerland, Greece, and Malta.

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