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COVID-19 Incidence and Mortality Among Unvaccinated and Vaccinated Persons Aged ≥12 Years by Receipt of Bivalent Booster Doses and Time Since Vaccination - 24 U.S. Jurisdictions, October 3, 2021-December 24, 2022
  COVID deaths 5-fold lower after bivalent vs monovalent booster:


During all periods, average weekly age-standardized incidence and mortality were consistently higher among unvaccinated persons (ranges = 216.1-1,256.0 and 1.6-15.8, respectively) than among monovalent-only vaccine recipients (ranges = 86.4-487.7 and 0.3-1.4, respectively); average weekly incidence and mortality during the late BA.4/BA.5 period were lowest among bivalent booster recipients (78.5 and 0.1, respectively).
Overall, age-standardized case RRs (unvaccinated persons compared with monovalent-only vaccine recipients) declined from 4.0 during the Delta period to 2.6 during the Omicron BA.1 and 1.8 during the Omicron BA.2 periods, before increasing to 2.7 in the early BA.4/BA.5 period. Overall case RRs (unvaccinated persons compared with bivalent booster recipients) were slightly higher (2.8) than were those for monovalent-only vaccine recipients (2.5) during the late BA.4/BA.5 period.

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