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Multiscale modeling of lead-in results from a phase 2 study of
an 8-week combination regimen of Bemnifosbuvir and Ruzasvir in
patients with chronic hepatitis C virus infection
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AASLD 2024 Nov 15-19 San Diego
Carolin Zitzmann1, Ruy M. Ribeiro1, Sergey Izmailyan2, Shannan Lynch2, Keith Pietropaolo2, Arantxa Horga2, Xiao-Jian Zhou2, Janet Hammond2, Alan S. Perelson1
1Theoretical Biology and Biophysics, Los Alamos National Laboratory, NM, United States 2Atea Pharmaceuticals, Inc., Boston, MA, United States
EASL2024: Bemnifosbuvir is a potent HCV NS5B inhibitor with a favorable antiviral profile and high resistance barrier/a>
AASLD2023: Bemnifosbuvir and ruzasvir are potent HCV DAAs with favorable antiviral profiles against major HCV NS5A and NS5B RAVs supporting use in combination/a>
EASL2023: Lead-in Cohort Results From a Phase 2 Study of a Novel 8-week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients With Chronic Hepatitis C Virus Infection
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