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Transaminase elevations among patients with
occult HBV infection on two-drug antiretroviral regimens
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CROI 2024 March 3-6 Denver
Luca Mezzadri1, Bianca Monti1, Alice Ranzani2, Anna Cappelletti2, Silvia Limonta2, Alessandro Soria2, Elisa Colella2, Ilaria C. Caramma2, Nicola Squillace2, Paolo Bonfanti1,2, Giuseppe Lapadula1,2
1: School of Medicine, University of Milano-Bicocca, Milan, Italy; 2: Infectious Diseases Unit, Fondazione IRCCS, San Gerardo dei Tintori, Monza, Italy
HBV Reactivation in PWH Switching to TDF/TAF Sparing Therapy
IDWeek 2023: Hepatitis B Reactivation in Persons with HIV with Positive Hepatitis B Core Antibody after Switching to Antiretroviral Therapy without Hepatitis B Activity
EACS 2023: Single center study on participants living with HIV with isolated anticore antibody (anti-HBc) switching to long acting cabotegravir-rilpivirine therapy: Results from the SCohoLART study
Hepatitis B Infection or Reactivation After Switch to 2-Drug Antiretroviral Therapy: A Case Series, Literature Review, and Management Discussion
"Those with isolated anti-HB core antibodies should, if possible, remain on anti-hepatitis B-containing ART; switches to regimens without tenofovir or FTC/3TC should be monitored for hepatitis B reactivation”, Paul Sax
Occult hepatitis B infection (OBI) refers to a condition where replication-competent HBV DNA is present in the liver, with or without HBV DNA in the blood, in individuals with serum HBsAg negativity assessed by currently available assays. The episomal covalently closed circular DNA (cccDNA) in OBI is in a low replicative state. https://www.sciencedirect.com/science/article/pii/S0168827820303573
Occult hepatitis B infection (OBI) refers to a condition where replication-competent HBV DNA is present in the liver, with or without HBV DNA in the blood, in individuals with serum HBsAg negativity assessed by currently available assays. The episomal covalently closed circular DNA (cccDNA) in OBI is in a low replicative state. Apart from the risk of viral reactivation upon immunosuppression and the risk of transmission of HBV, OBI has been implicated in hepatocellular carcinoma (HCC) development in patients with chronic HCV infection, those with cryptogenic or known liver disease, and in patients with HBsAg seroclearance after chronic HBV infection..
https://www.journal-of-hepatology.eu/article/S0168-8278(20)30357-3/fulltext
Occult hepatitis B virus (HBV) infection (OBI) refers to a condition in which replication-competent viral DNA is present in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing negative for the HBV surface antigen (HBsAg). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318873/
Occult HBV infection (OBI) is defined as HBV DNA detection in serum or in the liver by sensitive diagnostic tests in HBsAg-negative patients with or without serologic markers of previous viral exposure. https://www.hindawi.com/journals/heprt/2013/259148/
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